Important Discoveries Through Chance

The “Principle of Limited Sloppiness” is the phrase coined by Science to describe fortuitous or accidental discoveries such as the following stories of some of the most important discoveries which were brought upon by chance.

In 1791 Luigi Galvani was an anatomist at the University of Bologna. Galvani was investigating the nerves in frog legs, and had threaded some legs on copper wire hanging from a balcony in such a way that a puff of wind caused the legs to touch the iron railing. A spark snapped and the legs jerked violently (even today, we speak of being “galvanized” into action). In one unintended step, Galvani had observed a closed electrical circuit, and related electricity to nerve impulses.

In 1879, Louis Pasteur inoculated some chickens with cholera bacteria. It was supposed to kill them, but Pasteur or one of his assistants had accidentally used a culture from an old jar and the chickens merely got sick and recovered. Later, Pasteur inoculated them again with a fresh culture that he knew to be virulent, and the chickens didn’t even get sick. Chance had led him to discover the principle of vaccination for disease prevention.

Wilhelm Roentgen was experimenting with electrical discharges one evening at the University of Wurzburg in 1895. There was a screen coated with a barium compound lying to one side, and Roentgen noticed that it would fluoresce when an electrical discharge would occur in the tube he was watching. On reaching for the screen, Roentgen got his hand between the discharge tube and the screen and saw the bones of his own hand through the shadow of his skin. In 1901, Roentgen received the Nobel prize for his accidental discovery of X-rays.

Alexander Fleming was a young bacteriologist at St. Mary’s Hospital in London in 1928. One day in his cluttered laboratory, he noticed that a culture dish of bacteria had been invaded by a mold whose spore must have drifted in through an open window. Under the microscope, he saw that, all around the mold, the individual bacteria that he had been growing had burst. He saved the mold, and from it produced the first penicillin.

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